AMPA receptor modulator-1( —— )

Catalog No. M32776 CAS No. 2036074-41-4

AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.

Purity : >98% (HPLC)

COA

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HNMR

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MSDS

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Biological Information

Product Name

AMPA receptor modulator-1
Note

Research use only, not for human use.
Brief Description

AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Description

AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

iGluR
Recptor

iGluR
Research Area

——
Indication

——

Chemical Information

CAS Number

2036074-41-4
Formula Weight

341.71
Molecular Formula

C16H11ClF3NO2
Purity

>98% (HPLC)
Solubility

——
SMILES

O(C(F)(F)F)C1=C(C=2C=C3C(=C(C)C2)NC(=O)C3)C(Cl)=CC=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ravula S, et al. Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826.?

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